GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2294008 | 1 | rs2978982 | chr8:143763490 | PSCA | chr8:143761875-143764142:+ | 0.43 | 4.29 | 4.22E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs2985684 | 1 | rs2985697 | chr14:50092902 | RPL36AL | chr14:50085407-50087349:- | 0.26 | 4.26 | 4.89E-5 | Carotid intima media thickness |
| THYM | cis | rs4660306 | 1 | rs2993259 | chr1:46001550 | CCDC163P | chr1:45960581-45965646:- | -0.82 | -13.83 | 1.73E-24 | Homocysteine levels |
| THYM | cis | rs30187 | 1 | rs30378 | chr5:96121994 | ERAP1 | chr5:96096515-96149837:- | -0.32 | -4.13 | 7.77E-5 | Ankylosing spondylitis |
| THYM | cis | rs30187 | 1 | rs30379 | chr5:96122260 | ERAP1 | chr5:96096515-96149837:- | -0.32 | -4.13 | 7.77E-5 | Ankylosing spondylitis |
| THYM | cis | rs30187 | 1 | rs30380 | chr5:96122281 | ERAP1 | chr5:96096515-96149837:- | -0.32 | -4.13 | 7.77E-5 | Ankylosing spondylitis |
| THYM | cis | rs911119 | 1 | rs3088162 | chr20:23607752 | CST9 | chr20:23583049-23586610:- | -0.5 | -4.66 | 1.04E-5 | Chronic kidney disease |
| THYM | cis | rs10461617 | 1 | rs3099459 | chr5:56137170 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 9.03 | 1.94E-14 | Type 2 diabetes |
| THYM | cis | rs2251844 | 1 | rs3101443 | chr15:43912372 | ADAL | chr15:43622872-43646094:+ | -0.5 | -4.35 | 3.42E-5 | Tumor biomarkers |
| THYM | cis | rs7849270 | 1 | rs3118625 | chr9:131873256 | CRAT | chr9:131857075-131873070:- | -0.47 | -5.46 | 3.79E-7 | Blood metabolite ratios |
| THYM | cis | rs7849270 | 1 | rs3118632 | chr9:131901284 | CRAT | chr9:131857075-131873070:- | -0.42 | -4.98 | 2.82E-6 | Blood metabolite ratios |
| THYM | cis | rs7849270 | 1 | rs3124498 | chr9:131865493 | CRAT | chr9:131857075-131873070:- | -0.48 | -5.25 | 9.3E-7 | Blood metabolite ratios |
| THYM | cis | rs7849270 | 1 | rs3124499 | chr9:131868991 | CRAT | chr9:131857075-131873070:- | -0.48 | -5.25 | 9.3E-7 | Blood metabolite ratios |
| THYM | cis | rs7849270 | 1 | rs3124510 | chr9:131899690 | CRAT | chr9:131857075-131873070:- | -0.42 | -4.98 | 2.82E-6 | Blood metabolite ratios |
| THYM | cis | rs7849270 | 1 | rs3124511 | chr9:131901458 | CRAT | chr9:131857075-131873070:- | -0.47 | -5.4 | 4.92E-7 | Blood metabolite ratios |